The Substance 2024 Cast. It follows a fading celebrity who uses a black market drug that creates a much younger version of herself (margaret qualley) with unexpected side effects. Opening in theaters september 20 is ‘the.

Demi moore gives the performance of her career in ‘the substance,’ a gruesome horror epic that wickedly skewers our standards of female youth and beauty. Meet the talented cast and crew behind ‘the substance’ on moviefone.